About Vedere bio
Vedere Bio: Pioneering Vision Restoration Beyond Traditional Gene Therapy
Vedere Bio II is a biotechnology company that is revolutionizing the field of gene therapy. The company's mission is to restore vision loss, not just slow it down, by developing innovative treatments for inherited retinal diseases (IRDs). Vedere Bio II's approach goes beyond traditional gene therapy and aims to address the root cause of IRDs.
Inherited retinal diseases are a group of rare genetic disorders that affect the retina, the light-sensitive tissue at the back of the eye. These conditions can lead to progressive vision loss and blindness, often starting in childhood or adolescence. There are currently no effective treatments for most IRDs, making them a significant unmet medical need.
Vedere Bio II was founded in 2019 by a team of leading experts in ophthalmology and gene therapy. The company's approach is based on decades of research into the genetics and biology of IRDs. Vedere Bio II's scientists have identified novel targets and developed proprietary technologies that enable precise delivery of therapeutic genes to specific cells in the retina.
One key innovation from Vedere Bio II is its use of adeno-associated viruses (AAVs) as vectors for gene delivery. AAVs are small viruses that can infect human cells without causing disease. They have been extensively studied as potential vehicles for delivering therapeutic genes to treat genetic disorders such as IRDs.
However, traditional AAV-based gene therapies have limitations when it comes to treating complex diseases like IRDs. One challenge is achieving sufficient levels of transgene expression in all relevant cell types within the retina. Another challenge is avoiding immune responses that can limit efficacy or cause adverse effects.
Vedere Bio II has overcome these challenges by developing next-generation AAV vectors with enhanced specificity and potency. These vectors allow targeted delivery of therapeutic genes to specific cell types within the retina while minimizing off-target effects and immune responses.
Another key innovation from Vedere Bio II is its focus on restoring vision, not just slowing its loss. Traditional gene therapies for IRDs aim to slow down the progression of vision loss by replacing or supplementing defective genes in the retina. While this approach can be effective in some cases, it does not address the underlying damage to retinal cells.
Vedere Bio II's approach goes beyond gene replacement and aims to restore function to damaged retinal cells. The company's scientists have developed novel gene therapies that can activate dormant pathways within retinal cells and promote their survival and regeneration.
Vedere Bio II has a pipeline of promising gene therapy candidates for various IRDs, including Leber congenital amaurosis (LCA), Usher syndrome, and Stargardt disease. The company has already demonstrated proof-of-concept in preclinical studies and is now advancing its lead candidates towards clinical trials.
In addition to its innovative science, Vedere Bio II has a strong team with deep expertise in ophthalmology, genetics, and drug development. The company's leadership includes seasoned executives from top biotech companies such as Biogen and Novartis.
Vedere Bio II is also well-funded with backing from leading venture capital firms such as ARCH Venture Partners and F-Prime Capital. The company raised $77 million in a Series A financing round in 2019, one of the largest ever for a preclinical-stage biotech company.
Overall, Vedere Bio II is poised to make a significant impact on the field of gene therapy for inherited retinal diseases. Its innovative approach holds great promise for restoring vision to millions of people worldwide who suffer from these devastating conditions.
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