Synthex, inc. Review

About Synthex, inc.

Synthex, Inc. is a leading pharmaceutical company that specializes in discovering and designing drugs that target previously undruggable proteins. The company relies on its unique screening platforms, ToRPPIDO and ToRNeDO, to identify potential drug candidates that can effectively treat various diseases.

ToRPPIDO (Targeted Orthogonal Proteolysis by Induced Dimerization Optimization) is a platform that enables the identification of small molecules that can induce the degradation of specific proteins. This platform uses a technique called induced proximity to bring together two proteins – one being the target protein and the other being an E3 ubiquitin ligase – which results in the degradation of the target protein.

On the other hand, ToRNeDO (Targeted Orthogonal RNA Editing for Disease Optimization) is a platform that enables the identification of small molecules that can modulate RNA editing enzymes to correct genetic mutations associated with various diseases. This platform uses CRISPR-Cas9 technology to introduce specific mutations into cells and then screens for small molecules that can correct these mutations.

Synthex's unique screening platforms have enabled it to discover several promising drug candidates targeting previously undruggable proteins. One such candidate is SYN-004, which targets beta-lactam antibiotics and prevents their destruction by gut bacteria. Another candidate is SYN-005, which targets tau protein aggregation in Alzheimer's disease.

In addition to its drug discovery efforts, Synthex also offers contract research services to other pharmaceutical companies looking for assistance with drug discovery or development projects. These services include assay development, hit-to-lead optimization, medicinal chemistry optimization, preclinical studies, and more.

Synthex has assembled a team of experienced scientists who are dedicated to advancing drug discovery efforts using cutting-edge technologies like CRISPR-Cas9 and induced proximity. The company has also established partnerships with academic institutions and other pharmaceutical companies to further advance its research efforts.

Overall, Synthex, Inc. is a leading pharmaceutical company that is making significant strides in discovering and designing drugs that target previously undruggable proteins. Its unique screening platforms, ToRPPIDO and ToRNeDO, have enabled it to identify several promising drug candidates for various diseases. With its experienced team of scientists and partnerships with other institutions, Synthex is well-positioned to continue making significant contributions to the field of drug discovery.