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Nabriva Therapeutics Plc: Revolutionizing the Fight Against Serious Infections
In today's world, where antibiotic resistance is becoming a major concern, Nabriva Therapeutics Plc is a beacon of hope. The commercial-stage biopharmaceutical company is dedicated to developing novel antibiotics to treat serious infections. With its current focus on the pleuromutilin class of antibiotics, Nabriva aims to revolutionize the way we fight against infectious diseases.
Founded in 2006 and headquartered in Dublin, Ireland, Nabriva has come a long way since its inception. The company's mission is to address the unmet medical needs of patients suffering from serious infections caused by multidrug-resistant bacteria. With an experienced team of scientists and researchers, Nabriva has made significant progress in developing innovative solutions that can combat these deadly pathogens.
The Pleuromutilin Class of Antibiotics: A Game-Changer
Nabriva's primary focus is on developing antibiotics from the pleuromutilin class. These are naturally occurring compounds that have been used for decades in veterinary medicine but have only recently been explored for their potential use in humans.
Pleuromutilins work by inhibiting bacterial protein synthesis and disrupting cell wall formation. This makes them effective against a wide range of gram-positive bacteria such as Staphylococcus aureus (including MRSA), Streptococcus pneumoniae (including drug-resistant strains), and Enterococcus faecium (including vancomycin-resistant strains).
One of Nabriva's most promising drugs from this class is lefamulin (Xenleta®). Lefamulin was approved by the FDA in August 2019 for the treatment of community-acquired bacterial pneumonia (CABP) in adults. It is administered orally or intravenously and has shown excellent efficacy against common respiratory pathogens such as Streptococcus pneumoniae and Haemophilus influenzae.
Lefamulin has several advantages over existing antibiotics used to treat CABP. It has a unique mechanism of action that reduces the risk of cross-resistance with other classes of antibiotics. It also has excellent tissue penetration properties, allowing it to reach high concentrations at sites where infections occur.
In addition to lefamulin, Nabriva also has several other drugs under development from the pleuromutilin class that target different types of infections such as skin and soft tissue infections (SSTIs) caused by gram-positive bacteria.
A Commitment to Patient Safety
At Nabriva Therapeutics Plc., patient safety comes first. The company follows strict guidelines set forth by regulatory agencies such as FDA and EMA when conducting clinical trials for its drugs.
Nabriva conducts extensive preclinical studies before initiating clinical trials on humans to ensure safety and efficacy profiles are well understood before testing begins on human subjects. All clinical trials are conducted according to Good Clinical Practice guidelines set forth by regulatory agencies worldwide.
The company also collaborates with leading academic institutions around the world who share their commitment towards improving patient outcomes through innovative research initiatives aimed at discovering new treatments for infectious diseases caused by multidrug-resistant bacteria.
Conclusion
In conclusion, Nabriva Therapeutics Plc represents an exciting new chapter in our fight against serious infections caused by multidrug-resistant bacteria. With its focus on developing novel antibiotics from the pleuromutilin class, it offers hope for patients suffering from life-threatening illnesses like CABP or SSTIs caused by gram-positive bacteria.
As one can see from their track record so far - including FDA approval for lefamulin - they have already made significant strides towards achieving this goal while maintaining strict adherence standards regarding patient safety throughout all stages involved with drug development process; making them one worth keeping an eye out!
nabriva.com
