Applied biophysics, inc.

Applied Biophysics, Inc. is a leading biotechnology company that specializes in developing label-free real-time automated cell-based assays powered by the technology of ECIS. The company was founded by Nobel laureate Ivar Giaever and Charles Keese, who are renowned for their contributions to the field of biophysics.

The technology developed by Applied Biophysics, Inc. is based on the principle of electric cell-substrate impedance sensing (ECIS), which allows researchers to monitor changes in cellular behavior in real-time without using any labels or dyes. This innovative approach has revolutionized the way scientists study cellular processes and has led to numerous breakthroughs in fields such as drug discovery, toxicology, and cancer research.

One of the key advantages of ECIS technology is its ability to provide highly accurate and reproducible data. Unlike traditional methods that rely on fluorescent or radioactive labels, ECIS measures changes in electrical impedance across a cell monolayer using microelectrodes embedded within a culture dish. This allows researchers to obtain precise measurements of parameters such as cell adhesion, migration, proliferation, and apoptosis with minimal interference from external factors.

Another major benefit of ECIS technology is its versatility. It can be used with a wide range of cell types including primary cells, immortalized cells, stem cells, and tumor cells. Moreover, it can be adapted for use with different experimental setups such as multiwell plates or microfluidic devices.

Applied Biophysics offers a range of products based on ECIS technology including ZTheta instruments for high-throughput screening applications; Flow-Thru systems for continuous monitoring; Wound Healing assays for studying cell migration; Barrier Function assays for assessing epithelial barrier integrity; and Cell Invasion assays for evaluating metastatic potential.

In addition to its product offerings, Applied Biophysics also provides custom assay development services tailored to meet specific research needs. Its team of experienced scientists works closely with clients to design experiments that address their unique questions while ensuring high-quality data output.

Overall Applied Biophysics' label-free real-time automated cell-based assays powered by the technology of ECIS have become an essential tool for researchers worldwide who seek accurate results without compromising time efficiency or quality control standards when conducting experiments related to drug discovery toxicology cancer research etcetera making it one-of-a-kind solution provider in this space!